![]() Intravitreal steroids versus observation for macular edema secondary to central retinal vein occlusion. Management of macular edema due to central retinal vein occlusion – the role of aflibercept. Treasure Island, FL: StatPearls Publishing 2019. Associations of retinal artery occlusion and retinal vein occlusion to mortality, stroke, and myocardial infarction: a systematic review. No significant differences were seen between combination MLP-IVI or peripheral LPC-IVI relative to IVI monotherapy for final BCVA or OCT parameters in macular oedema secondary to RVO. Consistent results were observed when considering peripheral LPC-IVI to IVI in BRVO and CRVO. ![]() The same results were seen in subgroup analyses for macular laser without peripheral laser in BRVO and CRVO patients. Similarly, no significant differences were seen in final CMT ( p = 0.54), change in CMT ( p = 0.33), final CRT ( p = 0.90), change in CRT ( p = 0.97), or number of injections required ( p = 0.78). ![]() In comparing macular laser photocoagulation with IVI (MLP-IVI) in BRVO patients, no significant differences were seen in final BCVA ( p = 0.78) or change in BCVA ( p = 0.09) after treatment. ResultsĪ total of 10 studies were included, for which 362 eyes were randomized to LPC-IVI and 365 to IVI. The primary outcome was best-corrected visual acuity (BCVA), while secondary outcomes were central macular thickness (CMT), central retinal thickness (CRT), central subfield thickness (CST), number of IVIs received, and incidence of adverse events. Meta-analysis was conducted with a random effects model. Randomized controlled trials that reported relevant efficacy and/or safety parameters following LPC-IVI relative to IVI were included. Subjects/MethodsĪ literature search of MEDLINE, EMBASE and Cochrane CENTRAL was conducted from inception until March 2021. This meta-analysis investigates the efficacy and safety of intravitreal anti-VEGF injections (IVI) compared to combination laser photocoagulation and IVI (LPC-IVI) in treating macular oedema secondary to retinal vein occlusion (RVO).
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